Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents

Not Accessible

Your library or personal account may give you access

Abstract

A new photoacoustic flow cytometry was developed for real-time detection of circulating cells, nanoparticles, and contrast agents in vivo. Its capability, integrated with photothermal and optical clearing methods, was demonstrated using a near-infrared tunable laser to characterize the in vivo kinetics of Indocyanine Green alone and single cancer cells labeled with gold nanorods and Indocyanine Green in the vasculature of the mouse ear. In vivo applications are discussed, including selective nanophotothermolysis of metastatic squamous cells, label-free detection of melanoma cells, study of pharmokinetics, and immune response to apoptotic and necrotic cells, with potential translation to humans. The threshold sensitivity is estimated as one cancer cell in the background of 107 normal blood cells.

© 2006 Optical Society of America

Full Article  |  PDF Article
More Like This
In vivo flow cytometer for real-time detection and quantification of circulating cells

J. Novak, I. Georgakoudi, X. Wei, A. Prossin, and C. P. Lin
Opt. Lett. 29(1) 77-79 (2004)

Photothermal image flow cytometry in vivo

Vladimir P. Zharov, Ekaterina I. Galanzha, and Valery V. Tuchin
Opt. Lett. 30(6) 628-630 (2005)

In vivo photoacoustic time-of-flight velocity measurement of single cells and nanoparticles

M. Sarimollaoglu, D. A. Nedosekin, Y. Simanovsky, E. I. Galanzha, and V. P. Zharov
Opt. Lett. 36(20) 4086-4088 (2011)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved