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Confocal reflectance theta line scanning microscope for imaging human skin in vivo

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Abstract

A confocal reflectance theta line scanning microscope demonstrates imaging of nuclear and cellular detail in human epidermis in vivo. Experimentally measured line-spread functions determine the instrumental optical section thickness to be 1.7±0.1μm and the lateral resolution to be 1.0±0.1μm. Within human dermis (through full-thickness epidermis), the measured section thickness is 9.2±1.7μm and the lateral resolution is 1.7±0.1μm. An illumination line is scanned directly in the pupil of the objective lens, and the backscattered descanned light is detected with a linear array, such that the theta line scanner consists of only seven optical components.

© 2006 Optical Society of America

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