Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

High-resolution in vivo imaging of blood vessels without labeling

Not Accessible

Your library or personal account may give you access

Abstract

We demonstrate that both oxyhemoglobin and deoxyhemoglobin have sequential two-color, two-photon absorption properties that can serve as endogenous contrasts in microvasculature imaging. Using a sensitive modulation transfer technique, we are able to image hemoglobin in red blood cells with micrometer resolution, both in vitro and in vivo. We show that excellent contrast from hemoglobin without any labeling can be obtained in tissue.

© 2007 Optical Society of America

Full Article  |  PDF Article
More Like This
Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo

Zhongwei Zhi, Yeongri Jung, and Ruikang K. Wang
Opt. Lett. 37(5) 812-814 (2012)

Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo

Dong Li, Wei Zheng, Yan Zeng, Yi Luo, and Jianan Y. Qu
Opt. Lett. 36(6) 834-836 (2011)

Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo

Chi Zhang, Konstantin Maslov, and Lihong V. Wang
Opt. Lett. 35(19) 3195-3197 (2010)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved