Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Photoacoustic detection of metastatic melanoma cells in the human circulatory system

Not Accessible

Your library or personal account may give you access

Abstract

Detection of disseminating tumor cells among patients suffering from various types and stages of cancer can function as an early warning system, alerting the physician of the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease, while late stage detection can serve as an indicator of the effectiveness of chemotherapeutics. The prognostic value of exposing disseminating tumor cells poses an urgent need for an efficient, accurate screening method for metastatic cells. We propose a system for the detection of metastatic circulating tumor cells based on the thermoelastic properties of melanoma. The method employs photoacoustic excitation coupled with a detection system capable of determining the presence of disseminating cells within the circulatory system in vitro. Detection trials consisting of tissue phantoms and a human melanoma cell line resulted in a detection threshold of the order of ten individual cells, thus validating the effectiveness of the proposed mechanism. Results imply the potential to assay simple blood draws, from healthy and metastatic patients, for the presence of cancerous melanoma providing an unprecedented method for routine cancer screening.

© 2006 Optical Society of America

Full Article  |  PDF Article
More Like This
Handheld photoacoustic microscopy to detect melanoma depth in vivo

Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, and Lihong V. Wang
Opt. Lett. 39(16) 4731-4734 (2014)

In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents

Vladimir P. Zharov, Ekaterina I. Galanzha, Evgeny V. Shashkov, Nicolai G. Khlebtsov, and Valery V. Tuchin
Opt. Lett. 31(24) 3623-3625 (2006)

Direct visualization of changes of lymphatic function and drainage pathways in lymph node metastasis of B16F10 melanoma using near-infrared fluorescence imaging

Sunkuk Kwon, Germaine D. Agollah, Grace Wu, Wenyaw Chan, and Eva M. Sevick-Muraca
Biomed. Opt. Express 4(6) 967-977 (2013)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved